Findings from a recent research report that high tumoral expression of a growth factor called Granulocyte Colony Stimulating Factor (G-CSF) in breast cancer cells is linked with significantly improved survival in an important group of breast cancer that does not respond to hormonal therapy. This favourable outcome was observed in the absence of hypoxia-induced carbonic anhydrase IX (CAIX).
Contributors to this research include Dr Nazia Riaz, one of our faculty members, who is currently a post-doctoral fellow in Professor Torsten O Nielsen's lab at the University of British Columbia. This research was conducted in collaboration with Professor Shoukat Dedhar's group and the findings have been published in Cancers.
Preclinical studies suggest that interactions between G-CSF and CAIX regulate the trafficking and function of immune cells in the tumour microenvironment.
The research team investigated the clinical significance of this crosstalk by analysing the protein expression of G-CSF, macrophage marker CD163 and CAIX by immunohistochemistry on a well-characterised tissue microarray series of invasive breast cancers.
The results of this study demonstrate the prognostic significance of G-CSF in invasive breast cancer, whereby high expression serves as an indicator of better survival in aggressive non-luminal subtype in the absence of CAIX expression.
Read the full article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957699/