Welcome to the second issue of LABRAD 2025, a non-thematic edition that highlights the diversity and expanding horizons of diagnostic medicine across the Departments of Pathology and Radiology. This year is especially significant as the Department of Pathology and Laboratory Medicine celebrates 40 years of excellence at Aga Khan University, a milestone that underscores our enduring commitment to quality, innovation, and service.

This issue brings together a thoughtfully selected range of articles that reflect the needs and realities of modern laboratory and imaging practice. A featured contribution focuses on ALK-rearranged lung cancer, highlighting advances in diagnostic integration using immunohistochemistry, FISH, and next-generation sequencing. Complementary molecular pathology content further emphasizes the expanding role of clinically actionable biomarkers and precision oncology in lung cancer management. Emerging areas such as the application of artificial intelligence in laboratory practice are explored alongside updates on myeloid NGS panels, instructive case-based discussions in hematology, and clinically relevant insights from microbiology and HPV genotyping. The Radiology Update presents modern, evidence-based approaches to pelvimetry, underscoring the importance of selective imaging and standardized reporting in contemporary clinical care.

The Happenings and Polaroid sections highlight academic engagement and departmental achievements, including participation in national and international conferences and key institutional milestones. “The Best of the Past" offers a reflective perspective on professional growth and leadership within radiology practice. We hope this issue contributes to meaningful learning, promotes critical reflection, and inspires continued engagement within our community.

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