Research Groups: Human Nutrition

Deficiency of micronutrients, such as folic acid, vitamin B6 and vitamin B12 can lead to a number of diseases.  In 2001, a research group comprising Dr M. Perwaiz Iqbal, Dr Khawar Kazmi and Dr Mohammad Ishaq embarked on studying the role of these vitamins against the development of coronary artery disease in Pakistani population.Later on, Dr Najaf Ali Nadeem, Dr Ghulam Nabi Kakepoto and Dr Rehana Siddiqui also joined the group to investigate the deficiency of these micronutrients and other trace elements and the ensuing effects on Pakistani population.

Current Projects

  • Role of vitamins B6, B12 and folate, glutathione and cytokines in the development of coronary artery disease in Pakistani population.
  • Effect of folic acid on plasma homocysteine levels and arterial endothelial function among diabetics with acute myocardial infarction.
  • Folate, B12 and homocysteine in rheumatoid arthritis.


  • Pakistan Science Foundation


Recent Publications

  • Kazmi KA, Iqbal MP, Rahbar A, Mehboobali N.  Admission troponin T as a prognostic marker and its relationship to streptokinase treatment in patients with acute myocardial infarction.  Tropical Doctor, 2003; 33:18-22.

  • Iqbal MP, Frossard, PM.  Methylene tetrahydrofolate reductase gene and coronary artery disease.  J Pak Med Assoc 2003; 53:33-36.

  • Iqbal MP, Khan AH, Yousuf FA.  A simple and sensitive radioenzymatic assay for pyridoxal-5-phosphate in human plasma. Pak J Zool 2003; 35(3): 231-235.

  • Iqbal MP, Kazmi KA, Jafri HR, Mehboobali N.  N-Acetyl-β-D-glucosaminidase in acute myocardial infarction.  Exp Mol Med 2003; 35(4):275-278.

  • Iqbal MP, Mehboobali N, Sultana F, Khan FB, Burney IA, Kakepoto GN. Effect of methotrexate and folinic acid on accumulation of iron in mice. Medical Hypotheses 2003; 61(4): 444-45.

  • Iqbal MP, Kazmi KA, Mehboobali N, Rahbar A. Myoglobin - A marker of reperfusion as well as a prognostic indicator in patients with acute myocardial infarction.  Clin Cardiol 2004; 27, 144-150.

  • Iqbal MP, Mahmood S, Mehboobali N, Ishaq M, Fatima T, Parveen S, Frossard PM. Association study of the angiotensin-converting enzyme (ACE) gene G 2350A dimorphism with myocardial infarction.  Exp Mol Med 2004; 36(2): 110-115.

  • Iqbal MP, Ishaq M, Mehboobali N.  Increased levels of erythrocyte glutathione in acute myocardial infarction: An antioxidant defence.  J Pak Med Assoc 2004; 54(5):254-258.

  • Iqbal MP, Shafiq M, Mehboobali N, Iqbal SP, Abbasi K.  Variability in lipid profile in Pakistani patients with acute myocardial infarction. J Pak Med Assoc 2004; 54(11):544-549.

  • Iqbal MP, Shafiq M, Mehboobali N, et al.  Hypertriglyceridemia and low HDL-cholesterol are the major lipid abnormalities in normal Pakistani adults: are these contributing to the high rates of coronary artery disease in this population? Pak J Med Sci 2004; 20(4):385-391.


Dr Mohammad Ishaq - Professor of Cardiology - NICVD, Karachi

Group Members




Dr M. Perwaiz Iqbal

Professor of Biochemistry


Dr Khawar A Kazmi

Associate Professor


Dr Najaf Ali Nadeem

Asst. Professor of Cardiology


Dr Ghulam Nabi Kakepoto

Associate Professor of Hematology


Dr Rehana Siddiqui

Assistant Professor - CHS


Ms Naseema Mehboobali

Research Coordinator


Ms Siddiqa Perveen

Research Associate


Mr Ghulam Haider

Research Assistant