​Research Groups: Gene Regulation and Vaccine Development Research​

Dr. Sohail A. Qureshi
Principal Investiga

​My research interests are in the areas of gene regulation, epilepsy, vaccine development, and phyto-therapeutics and we have a number of currently ongoing projects all of which employ state-of-the-art molecular biology and biochemical methodologies.


  • Gene regulation in the archaeon Sulfolobus solfataricus

  • Vaccine development against HCV and HEV

  • Cancer

  • pilepsy

  • Assay development and identification of therapeutically useful phytocompounds.


  • HCV Vaccine Development - Higher Education Commission (2005-2008)

  • Epilepsy - University Research Council (2005-2008)





    Junaid Iqbal

    Research Associate


    Sagheer Ahmed

    Research Associate


    Zaigham Mahmood

    PhD Student


    Ahmad Yaqinuddin

    PhD Student


    Bhisham Harchandani

    Medical student (class of 2008)


    Danesh Kella

    Medical student (class of 2008)


    Ali Jawaid

    Medical student (class of 2007)




    • Qureshi, S.A., Sanders, P., Zeh, K., Whitney, M., Pollock, B., Desai, R., Whitney, P., Robers, M., Hayes, S.H. (2003). A one-arm homologous recombination approach for developing nuclear receptor assays in somatic cells. Assay & Drug Development Technologies 1(6):767-776

    • Roberti, M., Polosa, P. L., Musicco, C., Milella, F., QURESHI, S. A., Gadaleta, M. N., Jacobs, H. T., and Cantatore, P.  (1999). In vivo mitochondrial DNA-protein interactions in sea urchin eggs and embryos. Current Genetics 34: 449-458.

    • Qureshi, S. A., and Jackson, S. P.  (1998). Sequence-specific DNA binding by the Sulfolobus shibatae TFIIB homologue, TFB, and its effect on promoter strength. Molecular Cell 1:389-400.

    • Qureshi, S.A., Bell, S.D., and Jackson, S.P.  (1997). Factor requirements for transcription in the archaeon Sulfolobus shibatae.  EMBO Journal 16:2927-2936.

    • Qureshi, S. A., Khoo,B., Baumann, P., and Jackson S. P. (1995). Molecular cloning of the TFIIB homologue from Sulfolobus shibatae. Proceedings of the National Academy of Sciences (USA) 92:6077-6081.    

    • Qureshi, S. A., Baumann, P., Rowlands, T., Khoo, B., and Jackson, S. P. (1995). Cloning and functional analysis of the TATA-binding protein fromSulfolobus shibatae.  Nucleic Acids Research 23:1775-1781.  

    • Baumann, P., QURESHI, S. A., and Jackson, S. P.  (1995). Transcription - New insights from archaebacteria.  Trends in Genetics 11(7):279-283.

    • Qureshi, S. A., and Blake, R. D. (1995).  Sequence characteristics of a cervid DNA repeat family and its relationship to a similar family in Bovids.  Journal of Molecular Evolution 40:400-404.

    • Qureshi, S. A., and Jacobs, H. T.  (1993). Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA.  Nucleic Acids Research 21:2801-2808.

    • Qureshi, S. A., and Jacobs, H. T.  (1993). Characterization of a high-affinity binding site for a DNA-binding protein from sea urchin embryo mitochondria. Nucleic Acids Research 21: 811-816.


    • Project:      Gene Regulation in Archaea

      Collaborator: Dr Maria Ciaramella
      Institute of Protein Biochemistry, CNR
      Via Pietro Castellino 111
      80131 Naples 

    • Project:      Vaccine Development Against HCV (subtype 3a)

      Collaborator: Dr Saeed Hamid
      Department of Medicine
      Aga Khan University, Karachi, 

      Dr. Shahana Urooj Kazmi
      Department of Microbiology
      University of Karachi, 

    • Project:      Gene and Proteins Involved in Epileptogenesis

      Collaborator  Dr Shahid Baig
      Department of Neurology
      Aga Khan University, Karachi, 

    • Project:      Identification of Medicinally Useful Phyto-compounds.

      Collaborator  Dr Anwar Gilani
      Department of Biological & Biomedical Sciences
      Aga Khan University, Karachi,