| Drug | Sample type | Time of Sample Collection | Therapeutic Ranges
|
| Valproic Acid |  | Trough | 50 - 100 µg/ml |
| Tegretol | Trough | 4-12 µg/ml |
| Phenytoin | Trough | 10-20 ug/ml
|
| Phenobarbital | Trough
| 10-40 ug/ml |
Gentamicin | Peak testing (exactly 1 h after start of infusion of 3rd dose, or 1st dose in critically ill patients) Trough
| Adults Multiple daily dose Peak: 4-10 ug/ml Trough: 1-2 ug/ml
| Adult Once daily dose Trough <1 ug/ml
| Pediatrics trough conc.: <2ug/ml |
| Vancomycin | Trough concentrations should be obtained prior to the fourth or fifth dose. | Therapeutic concentration >10 ug/ml
| Trough 15-20 ug/ml |
Amikacin
| Peak testing (exactly 1 h after start of infusion of 3rd dose, or 1st dose in critically ill patients) Trough
| Amikacin-Once daily dose Trough = <1.0 ug/ml Peak = 56-64 ug/ml
| Amikacin-Multiple daily dose Trough = 5-10 ug/ml Peak = 15-30 ug/ml |
Cyclosporin | 
| Trough
| Post renal transplants: Upto 2 months 200-300 ng/ml 3 months 200 ng/ml 4-12 months 80-180 ng/ml
| Post liver transplants: ≤ 1 month 350-450 ng/ml
2-6 months 250-350 ng/ml >6 months 170-240 ng/ml
| Post bone marrow transplants: First 3-4 weeks 200- 300 ng/ml Until 3 months 100- 200 ng/ml |
| Tacrolimus | Trough | Target range for trough sample 3-20 ng/ml | Toxic >20 ng/ml |
Methotrexate | 
| Trough or sample collected after 72 hrs of therapy
| Non-toxic concentration <0.1 umol/l
|
| Lithium |   | Trough (Predose or after 12 hours post dose) | Therapeutic Range: 0.6 - 1.2 mmol/l | Toxic: >2.0mmol/l |
| Theophylline | Peak testing (after 2-4 hours post dose) Trough | Therapeutic Range 10-20 ug/ml |
| Digoxin | Peak (after 8 hours post dose) Trough | Therapeutic Range 0.6-1.2 ng/ml | Toxic >2.0ng/ml |
Special instruction: Mention drug dosing frequency, route and sample is trough or peak. Mention STAT on the request slip if results are needed shortly.
|
