Child Health and Mortality Prevention Surveillance​​ (CHAMPS)

The CHAMPS network aims at identifying the cause of death for under-5 mortality and stillbirths at 7 sites in Sub-Saharan Africa and South Asia through epidemiologic surveillance, by utilizing Minimally Invasive Tissue Sampling (MITS), laboratory diagnostics including conventional and advanced histopathology and molecular screening of various pathogens, verbal autopsy, and available clinical and demographic data.

​Pakistan is among the ten countries in the world with the highest under-5 mortality. The new CHAMPS site is in three catchment areas in Karachi, Pakistan. The program in Karachi is being carried in collaboration with Aga Khan University Hospital and University of Texas, Southwestern.​

Principal investigator

​​Dr. Momin Kazi

Project outline:

The CHAMPS network expanded its network to Karachi, Pakistan in 2022. The project has targeted 3 low-income catchment areas within Karachi which are:

Ali Akbar Shah

Ibrahim Hyderi Extension

Bhains Colony

The project aims at conducting the study in two major phases the first would be the formative research phase and the second is the Mortality Surveillance and MITS procedure ​

Project a​ctivities:

The first phase, namely the formative phase would include the following:

Conducted in-depth interviews and focus group discussions with key community leaders and informants for insights into the community's acceptability and CHAMPS in three low-income catchment areas in Karachi.

The second phase, namely the Mortality Surveillance and MITS procedure would include the following:

- The aim for Year 1 is to collect 50 MITS and approximately 450 NON MITS samples (These numbers would increase every year)

- Conduct verbal autopsy (VA) on all under-5 deaths and stillbirths.

- Assess and determine causes of death via systematic review of all available, relevant data for each death (i.e., through the DeCode Panel) Perform in-process quality assurance (QA) and quality control (QC) measures, including monitoring and training to ensure high quality data and protocol compliance

- Create an archive of clinical specimens in each site country, as well as contribute to an international archive located in Atlanta (US)

- Disseminate results to family members, community members, local and national public health authorities, and other key stakeholders on a routine basis