Centre for Regenerative Medicine

Publications

Professor El-Nasir M A Lalani, Founding Director, AKU-CRM

The Khatija and Mohan Manji Dhrolia Endowed Chair in Stem Cell Biology and Regenerative Medicine

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Papers

Mian, A., Zafar, U., Ahmed, S., Ottmann, O., & Lalani, E-N. (2021). Oncogene-independent resistance in Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL) is mediated by activation of AKT/mTOR pathway. Neoplasia, 23(9), 1016-1027. https://doi.org/10.1016/j.neo.2021.07.009

Sajid, A., Lalani, E-N., Chen, B., Hashimoto, T., Griffin, D., & Bhartiya, A. et al. (2021). Ultra-structural imaging provides 3D organization of 46 chromosomes of a human lymphocyte prophase nucleus. International Journal Of Molecular Sciences, 22(11), 5987. https://doi.org/10.3390/ijms22115987

Yusuf, M., Farooq, S., Robinson, I., & Lalani, E-N. (2020). Cryo-nanoscale chromosome imaging—future prospects. Biophysical Reviews, 12(5), 1257-1263. https://doi.org/10.1007/s12551-020-00757-7

Barr, D., Chan, D., Garfinkel, S., Hammatt, Z., Ichikawa, I., Lalani, E-N & Kalichman, M. et al. (2020). First meeting in Asia of the Asia Pacific Research Integrity Network. Accountability In Research, 27(2), 99-106. https://doi.org/10.1080/08989621.2020.1715220

Riaz, N., Idress, R., Habib, S., & Lalani, E-N. (2020). Lack of androgen receptor expression selects for basal-like phenotype and is a predictor of poor clinical outcome in non-metastatic triple-negative breast cancer. Frontiers In Oncology, 10. https://doi.org/10.3389/fonc.2020.01083

Rajput, S., Minhas, K., Azam, I., Shaikh, U., Hussain, A., & Lalani, E-N. (2019). LMP1 expression in bone marrow trephines of patients with multiple myeloma confers a survival advantage. Leukaemia & Lymphoma, 60(8), 1991-2001. https://doi.org/10.1080/10428194.2018.1563697

Riaz, N., Idress, R., Habib, S., Azam, I., & Lalani, E-N. (2018). Expression of androgen receptor and cancer stem cell markers (CD44+/CD24− and ALDH1+): prognostic implications in invasive breast cancer. Translational Oncology, 11(4), 920-929. https://doi.org/10.1016/j.tranon.2018.05.002

Ibrahim, S., Siddiqui, A., Siddiqui, A., Ahmed, W., Moss, P., & Lalani, E-N. (2016). Sociodemographic factors associated with IgG and IgM seroprevalence for human cytomegalovirus infection in adult populations of Pakistan: a seroprevalence survey. BMC Public Health, 16(1). https://doi.org/10.1186/s12889-016-3772-8

Sultana, A., Idress, R., Naqvi, Z., Azam, I., Khan, S., Siddiqui, A., & Lalani, E-N. (2014). Expression of the androgen receptor, pAkt, and pPTEN in breast cancer and their potential in prognostication. Translational Oncology, 7(3), 355-362. https://doi.org/10.1016/j.tranon.2014.04.004

Romanska, H., Salagierski, M., Bruton, R., Abel, P., Sosnowski, M., & Lalani, E-N. (2010). Doxazosin induces apoptosis in PTEN–positive androgen-independent PC cells via inhibition of A kt activation. Central European Journal Of Urology, 63, 91-97. https://doi.org/10.5173/ceju.2010.02.art8

Romanska, H., Tiziani, S., Howe, R., Günther, U., Gulzar, Z., & Lalani, E-N. (2009). Nuclear magnetic resonance detects phosphoinositide 3-kinase/akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts. Neoplasia, 11(12), 1301-1308. https://doi.org/10.1593/neo.09850

Sadej, R., Romanska, H., Baldwin, G., Gkirtzimanaki, K., Lalani, E-N., Novitskaya, V., & Filer, A. et al (2009). CD151 regulates tumorigenesis by modulating the communication between tumour cells and endothelium. Molecular Cancer Research, 7(6), 787-798. https://doi.org/10.1158/1541-7786.mcr-08-0574

Sheikh, S., Romanska, H., Abel, P., Domin, J., & Lalani, E-N. (2008). Predictive Value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer—a pilot study. Neoplasia, 10(9), 949-953. https://doi.org/10.1593/neo.08582

Langley, R.E., Godsland, I.F., Kynaston, H., Clarke, N.W., Rosen, S.D., Morgan, R.C., Pollock, P., Kockelbergh, R., Lalani, E.-N., Dearnaley, D., Parmar, M. and Abel, P.D. (2008), Early hormonal data from a multicentre phase II trial using transdermal oestrogen patches as first-line hormonal therapy in patients with locally advanced or metastatic prostate cancer. BJU International, 102: 442-445. https://doi.org/10.1111/j.1464-410X.2008.07583.x

Rehman, K., Parmar, S., Williams, R., Dover, S., & Lalani, E-N. (2008). Research training for oral and maxillofacial surgery. British Journal of Oral and Maxillofacial Surgery, 46(4), 343. https://doi.org/10.1016/j.bjoms.2007.11.016

Soeiro, I., Mohamedali, A., Romanska, H., Lea, N., Child, E., Lalani, E-N., & Glassford, J. et al. (2006). p27 Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. molecular and cellular biology, 26(16), 6170-6184. https://doi.org/10.1128/mcb.02182-05

Horne, A., Lalani, E-N., Margara, R., & White, J. (2006). The effects of sex steroid hormones and interleukin-1-beta on MUC1 expression in endometrial epithelial cell lines. Reproduction, 131(4), 733-742. https://doi.org/10.1530/rep.1.00883

Ockrim, J., Lalani, E-N., & Abel, P. (2006). Therapy insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy. Nature Clinical Practice Oncology, 3(10), 552-563. https://doi.org/10.1038/ncponc0602

Ockrim, J., Lalani, E-N., Aslam, M., Standfield, N., & ABEL, P. (2006). Changes in vascular flow after transdermal oestradiol therapy for prostate cancer: a mechanism for cardiovascular toxicity and benefit. BJU International, 97(3), 498-504. https://doi.org/10.1111/j.1464-410x.2006.05937.x

Horne, A., Lalani, E-N., Margara, R., Ryder, T., Mobberley, M., & White, J. (2005). The expression pattern of MUC1 glycoforms and other biomarkers of endometrial receptivity in fertile and infertile women. Molecular Reproduction And Development, 72(2), 216-229. https://doi.org/10.1002/mrd.20307

Baus-Loncar, M., Schmid, J., Lalani, E-N., Rosewell, I., Goodlad, R., & Stamp, G. et al. (2005). Trefoil factor 2 (Tff2) deficiency in murine digestive tract influences the immune system. Cellular Physiology And Biochemistry, 16(1-3), 31-42. https://doi.org/10.1159/000087729

Lalani, E-N., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., & Nanji, A. (2005). Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. International Journal Of Molecular Medicine. https://doi.org/10.3892/ijmm.15.5.811

Ockrim, J., Lalani, E-N., & Abel, P. (2005). Osteoporosis and spinal fractures in men with prostate cancer: risk factors and effects of androgen deprivation therapy. Journal Of Urology, 173(5), 1829-1829. https://doi.org/10.1097/01.ju.0000159531.57786.ae

Ockrim, J., Lalani, E-N., Kakkar, A., & Abel, P. (2005). Transdermal estradiol therapy for prostate cancer reduces thrombophilic activation and protects against thromboembolism. Journal Of Urology, 174(2), 527-533. https://doi.org/10.1097/01.ju.0000165567.99142.1f

Baus-Loncar, M., Al-azzeh, E., Romanska, H., Lalani, E-N., Stamp, G., Blin, N., & Kayademir, T. (2004). Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor κB and C/EBPβ. Peptides, 25(5), 849-854. https://doi.org/10.1016/j.peptides.2003.11.019

El Sheikh, S., Domin, J., Abel, P., Stamp, G., & Lalani, E-N. (2004). Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF. Neoplasia, 6(6), 846-853. https://doi.org/10.1593/neo.04379

Mubashar, M., Harrington, K., Chaudhary, K., Lalani, E-N., Stamp, G., & Peters, A. (2004). Differential effects of toremifene on doxorubicin, vinblastine and Tc-99m-sestamibi in P-glycoprotein-expressing breast and head and neck cancer cell lines. Acta Oncologica, 43(5), 443-452. https://doi.org/10.1080/02841860410031048

Ockrim, J., Lalani, E-N., Banks, L., Svensson, W., Blomley, M., & Patel, S. et al. (2004). Transdermal estradiol improves bone density when used as single-agent therapy for prostate cancer. Journal Of Urology, 172(6 Part 1), 2203-2207. https://doi.org/10.1097/01.ju.0000145511.56476.00

Khan, A., Abel, P D., Chaudhary, K S., Gulzar, Z., Stamp, G W H Stamp., Lalani, E-N. (2003). Inverse correlation between high-level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder. Molecular Pathology, 56(6), 353-361. http://dx.doi.org/10.1136/mp.56.6.353

Landles, C., Chalk, S., Steel, J., Rosewell, I., Spencer-Dene, B., Lalani, E-N., & Parker, M. (2003). The thyroid hormone receptor-associated protein trap220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Molecular Endocrinology, 17(12), 2418-2435. https://doi.org/10.1210/me.2003-0097

El Sheikh, S., Domin, J., Tomtitchong, P., Abel, P., Stamp, G., & Lalani, E-N. (2003). Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. BMC Clinical Pathology, 3(1). https://doi.org/10.1186/1472-6890-3-4

Ockrim, J., Lalani, E-N., Laniado, M., Carter, S., & Abel, P. (2003). Transdermal estradiol therapy for advanced prostate cancer—forward to the past?. Journal Of Urology, 169(5), 1735-1737. https://doi.org/10.1097/01.ju.0000061024.75334.40

Tadrous, P., Siegel, J., French, P., Shousha, S., Lalani, E., & Stamp, G. (2003). Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer. The Journal of Pathology, 199(3), 309-317. https://doi.org/10.1002/path.1286

Khan, A., Abel, P D., Chaudhary, K S., Gulzar, Z., Stamp, G W H Stamp., Lalani, E-N. (2003). Inverse correlation between high-level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder. Molecular Pathology, 56(6), 353-361. http://dx.doi.org/10.1136/mp.56.6.353

Landles, C., Chalk, S., Steel, J., Rosewell, I., Spencer-Dene, B., Lalani, E-N., & Parker, M. (2003). The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Molecular Endocrinology, 17(12), 2418-2435. https://doi.org/10.1210/me.2003-0097

Nightingale, J., Chaudhary, K., Abel, P., Stubbs, A., Romanska, H., Lalani, E-N & Mitchell, S. et al. (2003). Ligand activation of the androgen receptor downregulates e-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells. Neoplasia, 5(4), 347-361. https://doi.org/10.1016/S1476-5586(03)80028-3

Books/ Book Chapters

Abel, PD & Lalani, E-N. (2003). Prostate Cancer: Scientific and Clinical Aspects – Bridging the Gap. Imperial College Press, London, UK. ISBN 1-86094-327-6). Contributed 5 out of 38 chapters.

Lalani, E-N., Gendler, SJ., Peat, N., Duhig, T & Taylor-Papadimitriou, J. (1993). Model systems for studying the potential use of the breast associated mucin PEM, in cancer therapy. In AA ed, Monoclonal application in clinical oncology (138-167). Springer Verlag.

Anilkumar, TV., Golding, M., Sarraf, C., Lalani, E-N & Alison M. (1994). Stem cell activation in acetylaminofluorene treated regenerating rat liver: a bile ductular reaction (163-180). In Skoutris GG (Ed), NATO ASI Series. Springer Verlag.

Pignatelli, M., Liu, D., Nigam, AK., Gagliardi, G., Stamp, GW & Lalani, E-N. (1995). Adhesion molecules in neoplasia: an overview (1-14). In Epenetos AA and Pignatelli M (Eds), Cell adhesion molecules in cancer and inflammation. Harwood Academic Publishers.

Stamp, GW., Lalani, E-N., Hanby, AM., Rasbridge, S & Pignatelli, M. (1995). Cell adhesion molecules in mammary carcinoma (15-36). In Epenetos AA and Pignatelli M (Eds) Cell adhesion molecules in cancer and inflammation.
Harwood Academic Publishers.

Williams, R., Elia, G., Lalani, E-N & Stamp, GW. (1995). Neoplastic and hyperplastic alterations in pancreatic ductal epithelium. In Lemoine N and Neoptolemos J (Eds) Diseases of the pancreas. Blackwell Science Ltd, Oxford.

Lalani, E-N., & Stamp, GW. (1997). Role of the stroma in neoplastic growth and progression (102-124). In Lemoine N and Kirkham N (Eds) Progress in Pathology 3. Churchill Livingstone.

Lalani, E-N., Stubbs, A., & Stamp, GW. (1998). Molecular genetic changes in prostate cancer (113-135). In Lemoine N and Kirkham N (Eds) Progress in Pathology 4. Churchill Livingstone.

Abel, PD & Lalani, E-N. (2003). Prostate Cancer - Some clinical and scientific dilemmas (3-19). In Prostate Cancer – Clinical and Scientific Aspects – Bridging the Gap Part 1. Imperial College Press.

Mitchell, SE., Nightingale, J., Abel, PD & Lalani, E-N. (2003). Cell lines as models of prostate cancer (143-244). In Abel PD and Lalani E-N (Eds) Molecular and Cell Biology of Prostate Cancer Part 4, Ch1; Prostate Cancer – Clinical and Scientific Aspects – Bridging the Gap. Imperial College Press.

Laniado, ME., Lalani, E-N & Abel, PD. (2003). Ion channels in prostate cancer (339-358). In Abel PD and Lalani E-N (Eds) Molecular and Cell Biology of Prostate Cancer Part 4, Ch1; Prostate Cancer – Clinical and Scientific Aspects – Bridging the Gap. Imperial College Press.

Mitchell, SE., Abel, PD., Lalani, E-N & Hayward, SW. (2003). Epithelial-mesenchymal interactions in prostate cancer (421-454). In Abel PD and Lalani E-N (Eds) Molecular and Cell Biology of Prostate Cancer Part 4, Ch 1; Prostate Cancer – Clinical and Scientific Aspects – Bridging the Gap. Imperial College Press.

Chaudhary, KS., Abel, PD & Lalani, E-N. (2003). Bcl-2 family Proteins and prostate cancer progression: potential for therapeutic interventions (595-618). In Abel PD and Lalani E-N (Eds) Molecular and Cell Biology of Prostate Cancer Part 4, Ch1; Prostate Cancer – Clinical and Scientific Aspects – Bridging the Gap. Imperial College Press.

​Publications

Professor El-Nasir M A Lalani, Founding Director, AKU-CRM

The Khatija and Mohan Manji Dhrolia Endowed Chair in Stem Cell Biology and Regenerative Medicine

​​View Personal Profile​

Papers ​

Books/ Book Chapter​s​​

Publications

View Personal Profile

Papers

Books/ Book Chapters