​Cancer Stem Cell​​

Cancer remains a major global health burden. Traditional treatments such as surgery, radiotherapy, and chemotherapy have long been the standard of care. In recent years, targeted therapy and immunotherapy have expanded treatment options. Yet, limited efficacy and treatment resistance continue to challenge long-term success.

Cancer stem cells (CSCs) are a small but powerful group of cells within tumors. They can self-renew and continuously proliferate. These cells often survive conventional treatments. As a result, they contribute to relapse and metastasis. Researchers worldwide are now working to identify pathways that can specifically target and eliminate CSCs. Our research on cancer stem cells is centered on addressing this critical gap. ​​​​​

Rajput S, Minhas K, & Lalani ​E-N. (2019). Establishment and Characterisation of ​​a Myeloma Cell Line- AKU-MY01. Blood, 134(Supplement_1), 5535-5535. doi:10.1182/blood-2019-132238​

             
Rajput S, Minhas K, ​Azam I, Shaikh U, Hussain A, & Lalani E-N. (2019). LMP1 Expression in Bo​​ne Marrow Trephines of Patients With Multiple Myeloma Confers a Survival Advantage​. Leuk Lymphoma, 60(8), 1991-2001. doi:10.1080/10428194.2018.1563697.​​  
             
​Riaz N, Idrees R, Habib S, Azam I, & Lalan​i​ E-N. Expr​ession of Androgen Receptor and Cancer Stem Cell Markers (CD44+/CD24- and ALDH+): Prognostic Implications in Invasive Breast Cancer​.​ Translational Oncology. 2018. (doi: 10.1016/j.tranon.2018.05.002)​​ ​​