Experimental Medicine Platform (EMP)
Principal Investigator: Dr. Asad Ali
Co-PI: Dr. Najeeha Talat Iqbal, Dr. Junaid Iqbal
Funded by: Bill and Melinda Gates Foundation
Project duration: Ongoing
Project sites: Matiari and AKUH, Karachi, Pakistan. Bangladesh, Zambiya and Senegal
Primary Objective: To determine if a probiotic, Vivomixx, can reduce inflammation and epithelial damage in pregnant women with environmental enteropathy as assessed through plasma and fecal biomarkers in the target countries.
Secondary Objectives:
- To determine if Vivomixx can reduce enteropathogen colonisation.
- To determine if Vivomixx can impact the structure and function of the microbiome assessed through whole genome metagenomic sequencing.
- To determine if Vivomixx can reduce permeability.
- To determine if Vivomixx can impact the host metabolome in pregnant woman.
- To evaluate variability in endpoints across geographies and participating laboratories.
