Antimicrobial resistance (AMR) is a potentially life-threatening global issue and has wide ranging impact on morbidity, mortality, and healthcare costs. In Pakistan, irrational use of antimicrobials is one of the biggest contributors to the escalating problem of AMR. To overcome this problem, it is imperative to evaluate the routine antimicrobial prescribing practices among general physicians in Pakistan. The aim of this study is to reduce irrational use of antibiotics in the outpatient settings of the Aga Khan University Hospital (AKUH) of Pakistan and in its secondary care centers. This is a pre-post interventional study in which children of age ≥6 months and adults with no upper limit visiting the outpatient clinics of study sites for acute watery diarrhea, URTI, acute undifferentiated fever and Skin and soft tissue infections and those who will provide signed informed consent will be included. The study sites are Aga Khan University Hospital (AKUH) main campus, Aga Khan Hospital, Garden, Karachi, and Aga Khan Hospital for women, Karimabad. We intend to do 6 months surveillance until our targeted sample size will be achieved in the outpatient setting of study sites before and after implementation of intervention (introduce and provide training to the physicians on the application of disease specific clinical algorithms combined with Point of care- CRP for 2 months). Prescriptions of same physicians will be observed pre and post intervention to assess the difference in proportion of specific antibiotic prescriptions.