Expression of the Glutamatergic and Gabaergic Neurons

University Research Grand Round

February 14, 2019
8:30 am-9:30 am | Karachi

Medical College

ABOUT THE TOPIC

'Expression of the Glutamatergic and Gabaergic neurons in telencephelic area of Australian Parrots and Sparrows complement their response to pentylenetetrazole'

Epilepsy is common disorder that affects over 50 million people worldwide. Birds remain a promising yet largely under-explored model of epilepsy. This study reports the comparison of the response of two species of birds, Australian Parrots (APs) and Sparrows (SPs), to a pro-epileptic drug, Pentylenetetrazole (PTZ). PTZ injections caused myoclonic jerks (MCJs) and tonic clonic seizures (TCSs) in both species. The frequency of MCJs in APs was greater at the dose of 75 mg/kg compared to both 50 mg/kg and 25 mg/kg while it was not significantly different in SPs. The comparison of APs and SPs showed that the frequency of MCJs was greater in APs compared to SPs at 25 mg/kg and 75 mg/kg while its latency was reduced at 25 mg/kg and 50 mg/kg. Interestingly SPs had a reduced latency of TCSs compared to APs at 75 mg/kg. Glutamatergic (excitatory neurons) and Gabaergic (inhibitory neurons) cell count was conducted to determine an association with the epileptic response to PTZ. The Glutamatergic cell counts for SPs was significantly greater than APs and conversely the Gabaergic cell counts in APs was higher compared to SPs. The differences in the expression of excitatory and inhibitory neurons could explain the epileptic behavior of the two species of birds. This study shows that birds, and APs and SPs in particular, are a valid, interesting and under-explored model of epilepsy that should be further explored in order to understand the mysteries of epilepsy.

Presenter
Dr Fazal Arain, Assistant Professor & Coordinator MPhil Programme, Department of Biological & Biomedical Sciences, AKU

Format
Research Presentation 

Who should attend
All faculty members, residents & students

Organiser
Faculty of Health Sciences Research Committee

Image credit:

AKU

V E N U E

Anatomy and Surgery Learning Studio, 1st floor, Department of Biological and Biomedical Sciences, Medical College, AKU

C O N T A C T

Dr Romaina Iqbal 
Associate Professor
Community Health Sciences
021 3486 4832
romaina.iqbal@aku.edu

Mr Shakeeb Khan
Deans Office 
Medical College 
021 3486 4445
shakeeb.khan@aku.edu