Dr Salma Jahan

Team Lead, Assistant Professor

​​Salma Jahan 265.jpgDr Salma Jahan completed her BSc Honours in Molecular Biology from the University of Toronto, Canada in 2005. She then did her PhD in Molecular Biology from York University, Toronto, Canada in 2013 following which in 2014, she joined the Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden as a Postdoctoral Fellow. There she worked on patient-specific induced Pluripotent Stem Cell (iPSC) derived Neuro-Epithelial Stem (NES) cells. Her research work was focused on neurodevelopmental disorders specifically Autism Spectrum Disorder (ASD). 

Dr Jehan holds more than 15 years of experience in molecular biology, neurobiology and stem cell biology. Her expertise lies in generating iPSC derived neuro-epithelial-like stem cells (NES) and primary hippocampal neuronal cell cultures. She has been working with human-induced Pluripotent Stem Cell (hiPSC) derived NES, neurosphere culture and neurite outgrowth analysis. 

She has also been conducting cutting-edge research on primary hippocampal neuronal cell cultures including hippocampal slice, astrocyte and cortical neuronal cell cultures in mice and rat models. 

Dr Jahan has published in her area of research focus and is a member of the Society of Neuroscience, International Society of Stem Cell Research, and Swedish Developmental Biology Society. 


Research Interests

  • Development of disease-specific iPSC with a focus on neural diseases, development of cerebral organoids and their functional analysis
  • Setting up of an academic-clinical translational iPSC core. 

Publications

  • Shahsvani M, Pronk R, Lam M, Linker S, Salma J,...Falk A (2017). An invitro Model of Lissencephaly: Expanding the Role of dcx During Neurogenesis. Molecular Psychiatry,7:1674-1684.doi: 10.1038/mp.2017.175. Epub 2017 Sep 19. Link

  • Hashemi S, Salma J, Wales S, McDermott JC (2015). Pro-survival Function of MEF2 in Cardiomyocytes is Enhanced by β-Blockers. Cell Death Discovery, Article number: 15019. doi:10.1038/cddiscovery.Link

  • Dionyssiou M, Salma J, Bevzyuk M,….McDermott JC (2013). Krüppel-like Factor 6 (KLF6) Promotes Cell Proliferation in Skeletal Myoblasts through a TGFβ/Smad3 Specific Pathway. Skeletal Muscle, 3(1):7.Link 

  • Salma J & McDermott JC (2012). Suppression of a MEF2-KLF6 Survival Pathway by PKA Signaling Promotes Apoptosis in Embryonic Hippocampal Neurons. Journal of Neuroscience. 32(8):2790-2803.Link

  • Perry RL, Yang C, Soora N, Salma J, …. McDermott JC (2009). Direct Interaction Between Myocyte Enhancer Factor 2 (MEF2) and Protein Phosphatase 1 Alpha Represses MEF2-Dependent Gene Expression. Mol Cell Biol, 12:3355-66. Link