Principal Investigator Dr Sheikh Abdul Saeed

Reproductive Endocrinology group is engaged in studies focused towards better understanding of the interaction of the hypothalamic-pituitary-gonadal axis in carrying out reproductive functions. Group uses in vivo and in vitro methodologies in these investigations. Group has a well established cell culture laboratory to study response of tissues and cells from hypothalamic, pituitary and gonadal sources.

CURRENT PROJECTS

• Role of leptin in the secretion of  gonadotrophins from rat pituitary gland: Effect of age and sex
• Role of Orexins in the secretion of testosterone from testicular cells.
• Effect of Nigella Sativus extract on testicular functions.

• Pakistan Science Foundation

• Navarro CE, Abdul Saeed S, Murdock C, et.al.
  Regulation of cyclic AMP signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized GnRH neurons. Mol. Endocrinol, 17 (9): 1792-1804, 2003
• M. Perwaiz Iqbal, S. Abdul Saeed and Fakhra Sultana
  Production and characterisation of anti-dihydrofolate reductase monoclonal antibodies. Pakistan J. Zool., Vol. 33(1), pp 39-45, 2001
• M. Perwaiz Iqbal, S. Abdul Saeed, Shamim Pertani et.al.
  Additive Effect of Indomethacin and Methotrexate on Suppression of Growth in Rats. Biopharmaceutics & Drug Disposition, 20: 389-395, 1999

• Dr Pervez Iqbal, Professor of Biochemistry, Department of Biological and Biomedical Sciences
• Dr Anwer Gilani, Professor of Pharmacology, Department of Biological and Biomedical Sciences